 |
| phytopin® |
| From the heart of the pine |
| pine phytosterols |
| KEY QUALITIES OF PHYTOPIN® |
| • Highest level in Beta Sitosterol - Contains sitostanol |
| • Approved by the European Commission for its formulation in functional foods |
| • BSE / TSE free |
| • Regular production & Absence of toxicity |
| KEY HEALTH BENEFITS |
| • Cardiovascular health - Cholesterol reduction |
| • Prostate health |
| • Soothing agent in cosmetic formulas |
| FACTS |
According to World Health Report 2004, about 17 million people die every year
of cardiovascular diseases, particularly heart attacks and strokes. |
| High cholesterol causes a third of all cardiovascular diseases worldwide. |
By 2020, heart disease and strokes will become the leading cause of death and
disability worldwide, with the number of fatalities likely to reach more than 20 million
a year and by 2030 the figure will rise to more than 24 million a year. |
On average, a 10% lowering of cholesterol is able to reduce the risk of coronary heart disease by up to 20%. In France more than one third of the population has a hypercholesterolemia. |
| PHYTOSTEROLS |
Sterols are molecules present in plants and animals. Phytosterols are so called as they are from plant origin. Phytosterols are found naturally in vegetables, fruits, legumes, nuts and grains (table 1). Several sterols are present in plants, primarily beta-sitosterol, campesterol and stigmasterol. These phytosterols, or plant sterols, are essential components of the cell membranes of plants – a similar role to that played by cholesterol in animal cells. The structure of plant sterols is very similar to that of cholesterol, differing only in the side chain (Figure 1). Pine, oleaginous plant (soy, rapeseed, sunflower, olive) and some specific vegetal (pygeum africanum, saw palmetto…) are usual industrial sources. In pine, the tall oil dissolves the sterols of phytopin® and allows their extraction. |
| TABLE 1. |
| food source | STEROLS CONTENT (MG) PER CONTENT 100 G OF FOOD SOURCE |
| • SESAME SEED | 714 |
| • OLIVE OIL | 221 |
| • PEANUTS | 220 |
| • CARROTS | 12 |
|
The usually consumed food contains small quantities of sterols, a traditional diet bringing between
90 and 390 mg/day of phytosterol (variable according to the countries and the diet). |
| PHYTOPIN® DESCRIPTION |
| phytopin®, phytosterol pine extract, is a fine white powder, extracted from tall oil: |
| PHYTOPIN®- CHARACTERISTICS |
| • Sterol title (%) (GC) > 99 |
| Typical composition(%)(GC) |
| • Beta Sitosterol |
| • Sitostanol |
| • Campesterol10 |
| • Campestanol |
| • Other sterols |
|
| gure 1: structures of common sterols |
 |
| HEALTH BENEFITS |
| CHOLESTEROL LEVELS, LDL CHOLESTEROL AND RISK OF CARDIOVASCULAR DISEASE |
About thirty studies have been conducted using plant sterol-enriched foods, primarily spreads. Effects on serum LDL-cholesterol levels were very consistent with reductions falling in the range of 8-14%. In fact, 1.5 to 2 grams of plant sterols generally produce a significant decrease in serum LDL cholesterol levels |
| MECHANISM OF ACTION |
 |
| WITHOUT PHYTOPIN® |
| • Cholesterol enters the gut from food and bile. |
| • Usually 50 % of the cholesterol is absorbed into the bloodstream. |
| • About 50 % of the cholesterol is cleared out of the body. |
| WITH PHYTOPIN® |
| • phytopin® is ingested together with cholesterol containing foods. |
• Because phytopin® plant sterols are structurally similar.
to cholesterol, they compete for absorption into the intestine.Less cholesterol is absorbed from the gut. |
| • Unabsorbed cholesterol and plant sterols
are eliminated from the body. |
| OTHER EFFECTS OF PHYTOPIN |
phytopin® lowers LDL, or bad cholesterol levels. High density lipoprotein (HDL), or good
cholesterol levels, plasma triglycerides are unchanged with consumption of plant sterols.
Some studies report a reduction in serum carotenoids levels. Advice to consume five servings of fruit and
vegetables each day, including one carotenoid-rich serving, maintained serum beta carotene at baseline levels. |
| PROSTATE HEALTH |
Begnin prostatic hypertrophy (BPH), non malignant enlargement of the prostate can lead to obstructive urinary tract symptoms and reduce urinary flow. Today it is well established that intake of beta sitosterol (60 mg daily) will reduce urinary symptoms and improve flow parameters. phytopin® is used successfully in prostate health formulas due do its high content in beta sitosterol (75%). |
| EQUIVALENCE
WITH STEROLS TITLE |
1.5 g of phytopin® per day
about 1 liter of olive oil per day
(equivalence with Sterols title) |
| USES |
| BIOLOGICAL ACTIVITY | DAILY DOSE RECOMMENDED | MAIN APPLICATION |
| CARDIOVASCULAR HEALTH CHOLESTEROL REDUCTION | BETWEEN 1.5 AND 2 G | DIETARY SUPPLEMENTS: SOFT CAPSULES,
GELATINE CAPSULES
FUNCTIONAL FOODS: YOGHURTS, MARGARINES,
DAIRY PRODUCTS, CEREAL BARS… |
| PROSTATE HEALTH | 60 MG |
| SOOTHING AGENT EMOLLIENT | TOPIC APPLICATION | COSMETICS |
|
 |
| LABELLING GUIDELINES |
| THE EU HAS PUBLISHED REGULATIONS ON THE LABELLING OF PHYTOSTEROLS AND PHYTOSTANOLS IN FOODS. SEE COMMISSION REGULATION (EC) NO 608/2004. |
| PRODUCTS FORMULATED BY USING THE PHYTOPIN® MUST BE LABELLED AS FOLLOW: |
| • “with plant sterols |
| • the amount of added phytosterols (expressed in % or as g of plant sterols per 100 ml or 100 g of the food) |
| • a statement that the product is intended “for people who want to lower their blood cholesterol level |
• in the same field of vision as the particular required under point 3 above, there shall be a statement that the consumption of more than 3 g/day of added plant sterols should be avoided |
• a statement that patients on cholesterol lowering medication should only consume the product under medical supervision |
• easily visible and legible statement that the product may not be nutritionally appropriate for pregnant and breastfeeding women and children under the age of five years |
| an advice that the product is to be used as part of a balanced and varied diet, including regular consumption of fruits
and vegetables to help maintain carotenoid levels |
• a definition of a portion of the food or food ingredient concerned (preferably in g or ml) with a statement
of the plant sterol amount that each portion contains |
| THE U.S. FDA PROVIDES THE FOLLOWING MODEL HEALTH CLAIM FOR STEROLS |
“food containing at least 0.40 g per serving of vegetable oil sterols eaten twice a day with meals for daily total intake of at
least 0.8 g, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.
A serving of [name of the food] supplies _ gram(s) of plant sterols”. |
drt nutraceutics - we extract qualities from nature
Extracting and purifying the qualities from nature to enable improvements in diet, nutrition and health
is the specific field of expertise of drt nutraceutics. It developes ingredients that have a well-deserved reputation
of high quality and purity for dietary supplements, functional foods and cosmetics. |
